HARRICK PLASMA

Protein-resistant surfaces through mild dopamine surface functionalization

The synthesis and evaluation of new dopamine-based catechol anchors coupled to poly(ethylene glycol) (PEG) for surface modification of TiO2 are reported. Dopamine is modified by dimethylamine–methylene (7) or trimethylammonium–methylene (8) groups, and the preparation of mPEG-Glu didopamine polymer 11 is presented. All these PEG polymers allow stable adlayers on TiO2 to be generated through mild dip-and-rinse procedures, as evaluated both by variable angle spectroscopic ellipsometry and X-ray photoelectron spectroscopy. The resulting surfaces substantially reduced protein adsorption upon exposure to full human serum.

Wach, J. Y., B. Malisova, S. Bonazzi, S. Tosatti, M. Textor, S. Zürcher, K. Gademann

Chem. Eur. J.

14(34)

10579-10584

0000-00-00

2008

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