Effective biological and biomedical research requires specific control of the cellular microenvironment and biomaterial characteristics. Plasma treatment cleans, sterilizes and activates the surfaces of biomaterials through the introduction of functional groups without affecting the bulk. Increased hydrophilicity or hydrophobicity of material surfaces increase the adhesion, coverage and proliferation of cells or induce the formation of spheroids respectively. In addition, plasma treatment has been shown to improve biocompatibility and antibiofouling characteristics for numerous applications. As a result plasma treatments is used extensively for cell seeding, protein adsorption, biomaterial coating and implant surface activation. This page contains brief application summaries and relevant articles concerning the use of plasma treatment in biological and biomedical research.
Inexpensive, disposable and transparent, plasma treated polystyrene, or tissue culture plastic (TCP), is the most extensively used cell culture material, not only because of its aforementioned qualities but because of its biological affinity....read more
(3-Aminopropyl)triethoxysilane (APTES), an aminosilane originally developed as an adsorbent for affinity chromatography, has developed into a versatile tool for improving surface chemistry in cell studies and microfluidic device fabrication....read more
Microfluidic devices are rapidly becoming a more advantageous cell culture platform than macroscopic culture vessels (dishes, flasks and well-plates) for numerous applications. Two dimensional cell culture benefits from a vast pool of established...read more
Neuron morphology, proliferation and function are regulated by a complex system of chemical and biophysical cues cumulatively termed the neuronal niche. Researchers endeavoring to model neuron activity, develop functional tissues or test drug...read more