The present invention generally relates to systems and methods for determining molecular motion, for example, using nanostructures such as DNA origami structures. In certain embodiments, a nanostructure, such as a DNA origami structure, may be used to amplify molecular motion of a species. For example, a species, such as a protein, may be used to move a DNA strand, or other component, which the nanostructure may be immobilized relative to. Rotation or other movement of the component by the species may be determined by determining movement of the nanostructure. Such movement may be determined, for instance, using a signaling entity attached to the nanostructure. Various other embodiments are generally directed to methods of preparing such systems, kits involving such systems or methods, or the like.