A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed down stream of the mixing portion. A method of preparing a radio labeled complex includes flowing a radiometal solution com prising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radio labeled complex.
Reichert, David E., Paul J. A. Kenis, Tobias D. Wheeler, Amit V. Desai, Dexing Zeng, Birce C. Onal
University of Illinois; Washington University