HARRICK PLASMA

Microfluidic Affinity System Using PDMS and a Surface Modification Process

A microfluidic affinity system is designed to recognize, capture and separate target analytes from input solutions. This microfluidic affinity system employs fluidic channels fabricated by silicon-based lithography in a silicon substrate. The fluidic channels are patterned and replicated in a substrate, preferably polydimethylsiloxane, PDMS, by pattern transfer from a silicon wafer mold with reversed patterns fabricated by lithography. A novel three-step covalent binding method for surface modification employs the following steps to covalently immobilize an affinity ligand on the substrate: 1) a plasma treatment; 2) a silanization treatment; and 3) a crosslinking treatment.

Montemagno, Carlo D., Elsa I. Chang

N/A

US20040110199 A1

0000-00-00

2004-06-10

2007-03-07

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