HARRICK PLASMA

Method to monitor and quantify interphase nuclear envelope rupture events

The present invention provides an in vitro method for monitoring interphase nuclear envelope rupture events in a eukaryotic cell or screening or identifying compound capable of increasing or decreasing the intensity and/or frequency of interphase nuclear envelope rupture events in a eukaryotic cell. These methods relate on a protein having a cytosolic non-nuclear localization in interphase and a non-sequence specific DNA binding activity. Interphase nuclear envelope rupture events are characterized by the presence of the protein of the invention in the nucleus of the eukaryotic cell.

Piel, Matthieu, Matteo Gentili, R. A. A. B. Matthew, Nicolas Manel

WO2017140875A1

2017-08-24

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