Bioanalytical Recognition Surface with Optimised Recognition Element Density

The invention relates to a recognition surface on a carrier with an (in relation to the surface) optimal binding capacity for recognizing and binding one or more analytes from one or more samples brought into contact with this surface, wherein a) said recognition surface comprises a mixture of specific biological or biochemical or synthetic recognition elements for the recognition and binding of said analytes with components which are “neutral” in respect of these analytes, i.e. which do not bind these analytes, and b) said specific recognition elements, in relation to the entire recognition surface or any sub-surface thereof, take up less than a full monolayer. The invention also relates to a method for the qualitative and/or quantitative detection of one or more analytes in one or more samples, wherein said samples and if necessary further reagents are brought into contact with a recognition surface according to the invention, and changes in optical or electronic signals resulting from the binding of the analyte or of further tracer substances used for the analyte detection are measured.

Pawlak, M., G. L. Duveneck, N. P. Huang, S. M. De Paul, M. Textor, R. Hofer, E. Schurmann-Mader

US 20040253596 A1





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