HARRICK PLASMA

Synthesis and structure formation in dilute aqueous solution of a chitosan-DNA hybrid

In the following is described the combination of straight biochemical and organic routes to graft nucleotide sequences to a chitosan backbone. The resulting chitosan-g-ssDNA hybrid self-assembles into submicrometer size structures in dilute aqueous solution as assessed by atomic force and electron microscopy imaging. The hypothesis of self-assembly driven by chemical incompatibility between the amphiphilic chitosan and nucleic acid grafts is supported further by stability of the self-assembly against ionic strength and pH variations.

Safir, Ilyès, Kien Xuan Ngo, Jancy Nixon Abraham, Majid Ghahraman Afshar, Ewa Pavlova, Corinne Nardin

Polymer

79

29-36

2015

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