Oscillations in light-triggered logic microfluidic circuit

Control of droplets in microfluidic environments has numerous applications ranging from analysis and sample preparation for biomaterials synthesis (Mann and Ozin Nature 382:313-318, 1996) and medical diagnostics (Pipper et al. Nat Med 13:1259-1263, 2007) to photonics (Schmidt and Hawkins Nat Photonics 5:598-604, 2011). Here we study the oscillations present in a microfluidic circuit capable of sorting curable droplets on demand by triggering the circuit with UV-light. Prior to this paper we showed that a simple circuit can self-sort particles and produce a binary output, sorted or rejected stream of particles, based on the hydrodynamic resistance induced by the particles as they flow through the microfluidic channels. We showed that the cross-linking of droplets can modulate the resistance, and demonstrated particle switching by sorting of otherwise identical droplets of uncured and cured photocurable solution immersed in mineral oil solution. Before arriving at the sorting circuit, droplets made of a photocurable solution were illuminated by a UV-light from a mercury lamp, curing them. By tuning the outlet pressures, the switching threshold could be tuned so that uncured droplets were rejected while cured droplets were switched (Raafat et al. μTAS Proc 1826-1828, 2010; Cartas-Ayala et al. Small 9:375-381, 2013). Here we use this system to study the oscillations in this circuit due to particleparticle interactions in the circuit. The circuit oscillation can be used as a counter with a light ON/OFF switch. The circuit behavior agrees well with theoretical predictions of droplet oscillations. Furthermore, the circuit oscillations can be switched on or off by UV-light illumination. This experiment demonstrates switching of particles based on deformability, illustrates the switching of particles by using light, and the possibility of creating new managing schemes for droplets by combining light control with droplet generation-rate control.

Cartas-Ayala, Marco A., Laura Gilson, Chong Shen, Rohit Karnik

Microsystem Technologies





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