HARRICK PLASMA

Microfluidics-based single-step preparation of injection-ready polymeric nanosystems for medical imaging and drug delivery

Translation of therapeutic polymeric nanosystems to patients and industry requires simplified, reproducible and scalable methods for assembly and loading. A single-step in-line process based on nanocoprecipitation of oxazoline-siloxane block copolymers inflow-focusing poly(dimethylsiloxane) microfluidics was designed to manufacture injection-ready nanosystems. Nanosystem characteristics could be controlled by copolymer concentration, block length and chemistry, microchannel geometry,flow rate, aqueous/organicflow rate ratio and payload concentration. The well-tolerated nanosystems exhibited differential cell binding and payload delivery and could confer sensitivity to photodynamic therapy to HeLa cancer cells. Such injection-ready nanosystems carrying drugs, diagnostic or functional materials may facilitate translation to clinical application.

Liu, Kegang, Zhen Zhu, Xueya Wang, Daniel Gonzalves, Bei Zhang, Andreas Hierlemann, Patrick Hunziker

Nanoscale

7

16983-16993

2015

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