HARRICK PLASMA

Layer-by-layer assembled highly adhesive microgel films

Water-based adhesives which have strong adhesion and can simplify the adhesion process, endow the adhesives with desired functions are important for various applications. In this work, water-based highly adhesive films with drug delivery ability are fabricated by layer-by-layer (LbL) assembly of chemically cross-linked poly(allylamine hydrochloride)-dextran (PAH-D) microgels and hyaluronic acid (HA). Strong adhesion as high as 6.95 ± 0.92 MPa can be achieved when glass substrates deposited with LbL assembled PAH-D/HA films are slightly pressed together. Confocal laser scanning microscope (CLSM) measurements disclose that the strong adhesion originates from the intermixing of HA with PAH-D microgels at the interface of two contacted PAH-D/HA films. Free-standing PAH-D/HA films are released from substrate under assistance of a sacrificial layer for direct use as adhesives because PAH-D microgels have strong interactions with various surfaces. PAH-D/HA adhesive films can load negatively charged drugs such as ibuprofen based on electrostatic interaction between PAH-D microgels and ibuprofen molecules and release them in physiological conditions. Ibuprofen-loaded PAH-D/HA free-standing films can strongly glue periostea, promising their potential application as bioadhesives capable of accelerating the healing of damaged tissues or organs.

Zhang, Jianfu, Dongdong Chen, Yang Li, Junqi Sun

Polymer

54

4220-4226

2013

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