HARRICK PLASMA

Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning

Living-cell-based screens can facilitate lead discovery of functional therapeutics of interest. A versatile and scalable method is reported that uses dense arrays of nanowells for imparting defined patterns on monolayers of cells. It is shown that this approach can coordinate a multi-component biological assay by designing and implementing a high-throughput, functional nanoliter-scale neutralization assay to identify neutra-lizing antibodies against HIV.

Ozkumur, Ayca Yalcin, Brittany A. Goods, J. Christopher Love

Small

11

4643-4650

2015

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