HARRICK PLASMA

Control of gold nanoparticles based on circular DNA strand displacement

In this study, DNA strand displacement is utilized to control the aggregation of DNA/gold nanoparticles (AuNPs) based on circular DNA, in which DNA/AuNP conjugates are captured and released by adding different DNA signal strands. Using this strategy, single DNA/nanoparticle building blocks are capable of assembling into complex structures of two and three circular DNA/nanoparticles. The existence of these structures is demonstrated by gel electrophoresis and transmission electron microscopy (TEM) analysis. This advance has potential applications in controlling, transporting and detecting DNA/AuNP conjugates with subsequent manipulation of the structure and function of these assemblies.

Zhang, Cheng, Jingjing Ma, Jing Yang, Yafei Dong, Jin Xu

Journal of Colloid and Interface Science

418

31-36

2014

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